EUCAST https://www.eucast.org/ EUCAST en EUCAST https://www.eucast.org/main/typo3conf/ext/tt_news/ext_icon.gif https://www.eucast.org/ EUCAST TYPO3 - get.content.right http://blogs.law.harvard.edu/tech/rss Sat, 14 May 2022 08:12:02 +0200 Consultation (14 May - 15 June) on revised breakpoints for IV fosfomycin https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=490&cHash=f0df73530e347fe47262a532cde23bb8 EUCAST posted a general consultation on revised breakpoints for intravenous fosfomycin.... EUCAST posted a general consultation on revised breakpoints for intravenous fosfomycin. Consultation period 14 May - 15 June, 2022. Revised breakpoints will be published in breakpoint table 2023.

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Sat, 14 May 2022 08:12:02 +0200
Consultation on the availability of piperacillin and ticarcillin without inhibitors. https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=488&cHash=f3e61e3f92d3ebe97d34ee2db3dadca3 EUCAST is considering removing breakpoints for piperacillin without tazobactam and/or ticarcillin... EUCAST is considering removing breakpoints for piperacillin without tazobactam and/or ticarcillin without clavulanic acid but only if these agents are no longer used. 
If you in your country are still using either or both of these agents without an inhibitor, please inform the EUCAST Scientific Secratary John Turnidge

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Wed, 04 May 2022 15:43:57 +0200
A new version of the QC table for testing of antifungal agents is available https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=487&cHash=53e14a0f1c9253d4d6ac446c07e66ede A new version of the QC table for testing of antifungal agents is available on the website. A new version of the QC table for testing of antifungal agents is available on the website.

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Wed, 04 May 2022 15:42:05 +0200
Cefiderocol Rationale Document updated https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=485&cHash=340857366db12871bcea51c1da45c157 The Cefiderocol Rational Document has been revised. Link. The Cefiderocol Rational Document has been revised. Link

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Tue, 12 Apr 2022 14:46:15 +0200
RAST updated to include incubation beyond 8 hours https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=484&cHash=309307a01b56067919356090742df5c0 EUCAST Rapid AST directly from positive blood culture bottles, previously restricted to 4, 6 or 8... EUCAST Rapid AST directly from positive blood culture bottles, previously restricted to 4, 6 or 8 hour incubation, has now been validated for 16 - 20 h incubation with specific reading guidelines and interpretive criteria. This is for situations where reading after a shorter incubation/reading time could not be organised. 

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Tue, 12 Apr 2022 14:42:58 +0200
Guidance note on topical agents revised https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=483&cHash=a21d2d2a29410b3e73e1ae3b3d8c3593 Minor revision of the EUCAST Guidance on topical agents Minor revision and update of the EUCAST Guidance on topical agents.

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Tue, 12 Apr 2022 11:35:05 +0200
How to: ECOFFs—the why, the how, and the don'ts of EUCAST epidemiological cutoff values. CMI 2022. https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=482&cHash=33c06c2750a843056a5ec64da3321a12 How to: ECOFFs—the why, the how, and the don'ts of EUCAST epidemiological cutoff... How to: ECOFFs—the why, the how, and the don'ts of EUCAST epidemiological cutoff values

Identifying the MIC wild-type distribution and its delineation of species targeted for receiving antimicrobial agent breakpoints is an important first step for determining clinical breakpoints. Having the main responsibility in the European Committee on Antimicrobial Susceptibility Testing (EUCAST) for characterizing the wild-type distributions and setting epidemiological cut-off values (ECOFFs), we explain the why, the how, and frequent misconceptions of wild-type MIC distributions and ECOFFs.

DOI:https://doi.org/10.1016/j.cmi.2022.02.024

https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(22)00101-X/fulltext 

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Sat, 02 Apr 2022 11:33:03 +0200
New version of Broth microdilution of moulds (vs. 9.4) https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=481&cHash=8c2e4a8022c212c27ad80e1f24a475e7 A new version of the Broth microdilution of moulds (version 9.4 to replace 9.3) published 1 April,... A new version of the Broth microdilution of moulds (version 9.4 to replace 9.3) published 1 April, 2022.

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Fri, 01 Apr 2022 16:24:27 +0200
EUCAST abandons the term "intrinsic resistance" in favor of "expected resistant phenotype" https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=480&cHash=e6a33871b9efef82225399f1a3ce0493 For many years EUCAST and other committees have struggled with the term “intrinsic resistance”.... For many years EUCAST and other committees have struggled with the term “intrinsic resistance”.
There is no agreed definition and since breakpoints are always “exposure dependent” it is hard to agree on a definition which will survive changes in dosing, modes of administration and a sudden willingness to accept a new and higher level of toxicity because of a lack of alternatives.

One advantage of defining a species as an "expected resistant phenotype" or "expected susceptible phenotype" in relation to an agent or class of agents, is that susceptibility testing becomes unnecessary and it allows colleagues to report the isolate as resistant and susceptible, respectively, without having performed a test. Also it informs us of important characteristics, shortcomings and assets, of agents.

EUCAST has decided to replace the term “intrinsic” with the terms “expected susceptible phenotype” and “expected resistant phenotype”. For a species to be included in the “expected resistant phenotype”, 90% or more should be considered resistant (Klebsiella pneumoniae vs. ampicillin is an example). For a species to be included in the “expected susceptible phenotype” the wild type should be considered susceptible (S or I) to the agent and a very high proportion (99%) of isolates should be devoid of acquired resistance to the agent (Streptococcus pyogenes vs. benzylpenicillin is one example). However, there are many EUCAST documents in which the term "intrinsic resistance" was used. It will be a process over some time to purge guidelines, tables and SOPs of the term.

In both cases, susceptibility testing is best avoided. A result which goes against the expected phenotype should be viewed with suspicion.

A short paper has now been published in CMI. (doi: https://doi.org/10.1016/j.cmi.2022.03.007

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Fri, 25 Mar 2022 18:44:12 +0100
Cefiderocol disk diffusion with EUCAST criteria - publication in JAC https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=479&cHash=309ce0555892a83c94aef216eb4cf802 Cefiderocol: EUCAST criteria for disc diffusion and broth microdilution for antimicrobial... Cefiderocol: EUCAST criteria for disc diffusion and broth microdilution for antimicrobial susceptibility testing. Link to the JAC article.

The reproducibility of cefiderocol MIC determination using broth microdilution (BMD) in iron-depleted CAMHB (ID-CAMHB) was investigated, and the EUCAST disc diffusion (DD) method for cefiderocol susceptibility testing was developed and validated against reference BMD.

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Wed, 16 Mar 2022 09:14:42 +0100
Temocillin MIC vs. inhibition zone diameters https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=478&cHash=af74f97c7b3b6e473de62ad28088b89e MIC and zone diameter data on temocillin added to the Enterobacterales calibration/validation file... MIC and zone diameter data on temocillin added to the Enterobacterales calibration/validation file (28 February, 2022). For anyone using EUCAST disk diffusion AST criteria, the calibration/validation files will provide valuable information and allow laboratories to benchmark local efforts with files used for setting EUCAST MIC and zone diameter breakpoints. 

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Mon, 28 Feb 2022 09:49:33 +0100
A Pragmatic Approach to Susceptibility Classification of Yeasts without EUCAST Clinical Breakpoints https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=477&cHash=a27a786fb6cfe130e20193bdb093a5ca A Pragmatic Approach to Susceptibility Classification of Yeasts without EUCAST Clinical... A Pragmatic Approach to Susceptibility Classification of Yeasts without EUCAST Clinical Breakpoints,
by Karen Marie Thyssen Astvad, Sevtap Arikan-Akdagli and Maiken Cavling Arendrup. 

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Fri, 25 Feb 2022 18:28:26 +0100
ECOFFs – the why, the how and the don´ts of EUCAST epidemiological cutoff values. https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=476&cHash=627b21425d234deacc5eb609f762931a Identifying the MIC wild type distribution and its delineation of species targeted for receiving... Identifying the MIC wild type distribution and its delineation of species targeted for receiving antimicrobial agent breakpoints is an important first step for determining clinical breakpoints. Having the main responsibility in EUCAST for characterizing the wild-type distributions and the setting of epidemiological cutoff values (ECOFFs), we explain the why, the how and frequent misconceptions of wild-type MIC distributions and ECOFFs.

A narrative review in CMI on the use of ECOFFs is now available in CMI. 

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Thu, 24 Feb 2022 12:25:49 +0100
Warning concerning MH broth for Thermofisher cefiderocol MIC panels. https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=475&cHash=49c2950f198b7cefd42216e7fd3639b3 Thermofisher/Sensititre have issue a warning against a malfunctioning broth for Sensititre panels... Thermofisher/Sensititre have issue a warning against a malfunctioning broth for Sensititre panels containing cefiderocol resulting in too low cefiderocol MIC-values.
The recommendation from the manufacturer is to ignore cefiderocol results unless you can confirm with the manufacturer that the warning does not concern the material used in your laboratory. 

The EUCAST recommendation is to report the malfunction to Thermofisher and to trust the disk diffusion test. Results outside the ATU are very robust. 

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Sat, 19 Feb 2022 14:47:58 +0100
Panel of well characterized P. aeruginosa strains available through EUCAST/CCUG. https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=474&cHash=cc5341aadb0f7df0acae7a1c462a2461 Nine phenotypically and genetically well characterized P. aeruginosa made available through... Nine phenotypically and genetically well characterized P. aeruginosa made available through EUCAST/CCUG.

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Mon, 31 Jan 2022 18:16:54 +0100
EUCAST system for abbreviating antimicrobial agents - update https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=473&cHash=940a0ef3c6b94e3fe356027047e477f6 EUCAST system for antimicrobial name abbreviations (January 2022). Previous version (13... EUCAST system for antimicrobial name abbreviations (January 2022). Previous version (13 July, 2018) 

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Thu, 27 Jan 2022 08:46:12 +0100
AFST comment on AST of dermatophytes https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=472&cHash=f3c2ec023cf2de1c420a3831e28e8b20 From the EUCAST Antifungal subcommittee (AFST): Comment on: Multicentre validation of a EUCAST... From the EUCAST Antifungal subcommittee (AFST): Comment on: Multicentre validation of a EUCAST method for the antifungal susceptibility testing of microconidiaforming dermatophytes. 

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Tue, 25 Jan 2022 09:13:43 +0100
The table listing breakpoints and ECOFFs for antifungal agents and relevant fungi is now updated. https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=471&cHash=9683eb4feaa642cca1d809639fea5ef3 Antifungal agents have MIC distributions in the EUCAST MIC distribution database. ECOFFs are... Antifungal agents have MIC distributions in the EUCAST MIC distribution database. ECOFFs are assessed and revised as new data is available. Also clinical breakpoints are regularly assessed and sometimed revised. The EUCAST AFST subcommittee posts a table comparing breakpoints and available ECOFFs (and TECOFFs). This table is now reviewed and revised. 

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Tue, 18 Jan 2022 19:24:22 +0100
All MIC/Zone diameter calibration file updated. Anaerobic bacteria added. https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=470&cHash=ec4a20fc82163fa62a12c81bd78a346f With changes in the breakpoint table v 12.0 and the adding of disk diffusion criteria for anaerobic... With changes in the breakpoint table v 12.0 and the adding of disk diffusion criteria for anaerobic bacterial and for Vibrio spp, the calibration files showing the relationship between MIC and inhibition zone diameters​​​​​​​ need updating. These are now available (Vibrio spp to follow). 

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Sun, 16 Jan 2022 21:24:33 +0100
EUCAST/ESPID joint task force on dosing of antibiotics in children - questionnaire on common practices. https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=469&cHash=4a65a1c7f3ecbcce8305277483a82954 EUCAST and ESPID are preparing to address antibiotic dosing and exposure in children to match... EUCAST and ESPID are preparing to address antibiotic dosing and exposure in children to match the current EUCAST recommendations for adults

To initiate discussion and development we encourage colleagues to answer the questionnaire on current practices in children.

Colleagues in clinical microbiology are encouraged to involve colleagues in paediatrics.

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Tue, 11 Jan 2022 16:35:34 +0100
Delafloxacin ECOFFs and TECOFFs published https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=468&cHash=9d4cef165c6d3587aa02a4e5d9b9743d Delafloxacin, a recent addition to the quinolone agents, has now received ECOFFs and TECOFFs. Delafloxacin, a recent addition to the quinolone agents, has now received ECOFFs and TECOFFs. 

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Sat, 08 Jan 2022 17:57:22 +0100
Happy New Year from the EUCAST https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=467&cHash=c3b8750523ae9d4bbbb8f9431f1227e9 This is to wish all EUCAST users a happy and successful new year and to summarise some recent... This is to wish all EUCAST users a happy and successful new year and to summarise some recent changes and additions to the EUCAST system. 

Ongoing projects for 2022:

  • Nocardiae breakpoints and AST methodology
  • Revised breakpoints for Corynebacterium diphtheriae and Corynebacterium ulcerans
  • Review of breakpoints and methods for viridans streptococci.
  • Extension of the list of agents with breakpoints for anaerobic bacteria
  • RAST - criteria for extended incubation time beyond 8h.
  • Dosing tables for paediatrics in collaboration with ESPID (European Society of Paediatric Infectious Diseases) 
  • ......
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Sat, 01 Jan 2022 17:25:03 +0100
Disk diffusion criteria and revised breakpoints for anaerobic bacteria https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=466&cHash=a14dff92d8dd427b3cb69167643de4d3 Disk diffusion methods and criteria and revised breakpoints for anaerobic bacteria now available. Disk diffusion methods and criteria and revised breakpoints for anaerobic bacteria now available.

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Tue, 28 Dec 2021 18:28:57 +0100
RAST breakpoints and QC criteria updated https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=465&cHash=8649abeaf79c258bec3e3691335b695f Rapid AST directly from positive blood culture bottles: breakpoints and QC updated to match the... Rapid AST directly from positive blood culture bottles: breakpoints and QC updated to match the regular EUCAST breakpoints.

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Tue, 28 Dec 2021 18:22:36 +0100
Breakpoint tables and dosages v 12.0 (2022) published https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=464&cHash=ea8540c0fbdaa71b3bbcb3bf765239de The revised breakpoint table (v 12.0) and dosages now published. Valid from 1 January, 2022. The revised breakpoint table (v 12.0) and dosages now published. Valid from 1 January, 2022.

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Tue, 28 Dec 2021 18:18:58 +0100
Guidance document update https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=463&cHash=741fb42fa822f66ba7f31b741a7a5030 Setting breakpoints for agent-inhibitor combinations was updated 14 December, 2021 Setting breakpoints for agent-inhibitor combinations was updated 14 December, 2021

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Tue, 14 Dec 2021 08:29:41 +0100
Recording of online seminar on EUCAST disk diffusion testing of anaerobic bacteria available https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=462&cHash=eaf9b9c644a289b010d4a4fdb5ac6cc7 On 9 December at 8AM, 1PM and 4PM, EUCAST organised an online seminar with contributions from... On 9 December at 8AM, 1PM and 4PM, EUCAST organised an online seminar with contributions from several colleagues who have taken part in the development of the new EUCAST disk diffusion of anaerobic bacteria.

Here is a recording of one of three "identical" seminars. 

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Thu, 09 Dec 2021 18:20:13 +0100
Disk diffusion of anaerobic bacteria - online seminar! https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=461&cHash=f178cce9e5218846761826f2ef5c5348 The 9th of December at 8AM, 1PM and 4PM there is an open online seminar on the new EUCAST disk... The 9th of December at 8AM, 1PM and 4PM there is an open online seminar on the new EUCAST disk diffusion test for AST of anaerobic bacteria.

Links to join are here

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Wed, 08 Dec 2021 16:58:06 +0100
Recording of online seminar on the new breakpoint table available https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=460&cHash=686631851b56487996a1952dfc7bcfb9 A recording of the online seminar on the new breakpint table is now available. A recording of the online seminar on the new breakpint table is now available.

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Sat, 04 Dec 2021 18:25:25 +0100
Breakpoint Table v 12.0 (2022) on consultation https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=459&cHash=160a5b91371e598957e10178fb3aa143 Next year´s breakpoint table, v 12.0, is on consultation from 3 - 20 December 2021 Next year´s breakpoint table, v 12.0, is on consultation from 3 - 20 December 2021

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Fri, 03 Dec 2021 07:37:16 +0100