EUCAST https://www.eucast.org/ EUCAST en EUCAST https://www.eucast.org/main/typo3conf/ext/tt_news/ext_icon.gif https://www.eucast.org/ EUCAST TYPO3 - get.content.right http://blogs.law.harvard.edu/tech/rss Mon, 26 Oct 2020 21:21:19 +0100 Invitation to EUCAST general updates via zoom https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=395&cHash=bd122529bcdc06b9adef325525285eb0 This is a general invitation to attend EUCAST zoom updates on the 11th of November (8 AM, 1 PM and... This is a general invitation to attend EUCAST zoom updates on the 11th of November (8 AM, 1 PM and 4 PM). Current EUCAST projects will be described, the next breakpoint table summarised and there will be opportunities to discuss. 

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Mon, 26 Oct 2020 21:21:19 +0100
Fluoroquinolone breakpoint adjustments - consultation. https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=394&cHash=3cb33e88aade7d173f8dc50b30cac323 Flurorquinolone breakpoint adjustments to Campylobacter, Corynebacteria and Bacillus - consultation... Flurorquinolone breakpoint adjustments to Campylobacter, Corynebacteria and Bacillus - consultation 12 - 31 October, 2020.

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Mon, 12 Oct 2020 09:09:56 +0200
Achromobacter xylosoxidans - method and breakpoints proposed. https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=393&cHash=8efc101146495cb0c4d901fc511afff1 Achromobacter xylosoxidans - method and breakpoints proposed - consultation 5 October - 31 October,... Achromobacter xylosoxidans - method and breakpoints proposed - consultation 5 October - 31 October, 2020.]]> Mon, 05 Oct 2020 15:22:25 +0200 EUCAST reference BMD for M. tuberculosis complex now published https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=392&cHash=f4945d6933df654a5a60f797810c3274 EUCAST reference BMD for M.tuberculosis complex susceptibility testing. EUCAST reference BMD for M.tuberculosis complex susceptibility testing.

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Fri, 04 Sep 2020 10:30:52 +0200
Consultation on breakpoints relevant for meningitis. https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=391&cHash=e4bfd34f8ee85650ce943f0a11133c44 EUCAST has reviewed and in some instances proposed a revision of breakpoints relevant to the... EUCAST has reviewed and in some instances proposed a revision of breakpoints relevant to the treatment of bacterial meningitis. The general consultation is open 1 September - 16 October, 2020.

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Mon, 31 Aug 2020 08:48:55 +0200
Burkholderia pseudomallei methods and MIC/zone correlates now available. https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=390&cHash=92ef60baaab9a71ed77e722f4b1a7766 Burkholderia pseudomallei methods and MIC/zone correlates now available. Multilaboratory trial... Burkholderia pseudomallei methods and MIC/zone correlates now available.

Multilaboratory trial published.

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Mon, 31 Aug 2020 08:39:39 +0200
Bacillus spp breakpoints - Consultation 25 Aug - 25 Sep. https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=389&cHash=2646ee9c042b8f38a608fdac4a4048f4 EUCAST proposes breakpoints for Bacillus spp (except B. anthracis) - consultation 25 August - 25... EUCAST proposes breakpoints for Bacillus spp (except B. anthracis) - consultation 25 August - 25 September, 2020.

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Tue, 25 Aug 2020 21:09:02 +0200
EUCAST clinical trial of blood culture RAST in 55 laboratories published. https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=388&cHash=b7540ea3a0add782ac7d8c68adcf5733 Following the initial development, published in 2019, a clinical trial in 55 laboratories was... published in 2019, a clinical trial in 55 laboratories was performed and published in 2020. ]]> Fri, 14 Aug 2020 11:57:27 +0200 SOP 3, 4, 7 and 8 updated https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=387&cHash=3c03a83a121379ba089ef95d3eb47d52 SOP 3, 4, 7 and 8 updated SOP 3, 4, 7 and 8 updated ]]> Thu, 30 Jul 2020 11:48:34 +0200 Ceftazidime-avibactam rationale document published https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=386&cHash=6e1bf450ba57008454442c9623afe943 Ceftazidime-avibactam RD available. Ceftazidime-avibactam RD available.]]> Thu, 30 Jul 2020 08:47:33 +0200 Interpretation of breakpoints for antifungal agents when definitions of S, I and R have changed - publication in CMI. https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=385&cHash=ab61ad795d7764fb161069b395ae6cad How to interpret MICs of antifungal compounds according to the revised clinical breakpoints v. 10.0... How to interpret MICs of antifungal compounds according to the revised clinical breakpoints v. 10.0 European committee on antimicrobial susceptibility testing (EUCAST). Arendrup et al. Clin Microbiol Infect. 2020; https://doi.org/10.1016/j.cmi.2020.06.007 

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Thu, 23 Jul 2020 09:48:39 +0200
Public consultation on piperacillin-tazobactam breakpoints and meningitis breakpoints. https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=384&cHash=9746bb6c70b5d00b8b19e9fcd67cb713 There are proposed changes to piperacillin-tazobactam breakpoints for Enterobacterales. There are... general consultation 17 July - 15 September, 2020.]]> Fri, 17 Jul 2020 20:25:12 +0200 Oral cephalosporins and Enterobacterales breakpoints - updated guidance document. https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=383&cHash=c9253ac333d5752dfa66e44e737f8467 Oral cephalosporins and Enterobacterales breakpoints - updated guidance document. Oral cephalosporins and Enterobacterales breakpoints - updated guidance document. ]]> Tue, 14 Jul 2020 11:12:48 +0200 SOP 9 revised (9.2) and SOP 11.0 published. https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=382&cHash=7b7abba879757aa56ac6cf851137a31b SOP 9 (on determining disk diffusion breakpoints and QC criteria) and SOP 11.0 (on determining the... SOP 9 (on determining disk diffusion breakpoints and QC criteria) and SOP 11.0 (on determining the disk content/potency). ]]> Mon, 13 Jul 2020 21:53:17 +0200 Ceftolozane-tazobactam disk criteria for H. influenzae https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=381&cHash=861f4da76a4259a53123ea6cc8e8027c Ceftolozane-tazobactam zone diameter breakpoints for H. influenzae now available. as an addendum to... Ceftolozane-tazobactam zone diameter breakpoints for H. influenzae now available. as an addendum to the EUCAST breakpoint table 10.0. The zone diameter breakpoints will be included in the regular breakpoint table 11.0. ]]> Tue, 16 Jun 2020 09:11:28 +0200 EUCAST on Twitter (@EUCAST_EUCAST) https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=380&cHash=e05e780ff4f658d7c8200c03d807fbed Try @EUCAST_EUCAST on twitter Try @EUCAST_EUCAST on twitter

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Thu, 04 Jun 2020 11:55:38 +0200
S.pneumoniae (10 strains) with reference MICs now available from EUCAST/CCUG. https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=379&cHash=ec284e36732d1c8e5b8ab5ac6a656137 EUCAST and CCUG in collaboration have made a panel of 10 strains with reference MICs available.... a panel of 10 strains with reference MICs available. Strains were selected on the basis of the varying susceptibility to betalactam agents. ]]> Thu, 04 Jun 2020 10:56:15 +0200 Ceftolozane-tazobactam rationale document published https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=378&cHash=75e9a62acd88b4afe1ea8ab91ef13129 Ceftolozane-tazobactam rationale document published. Ceftolozane-tazobactam rationale document published.

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Fri, 15 May 2020 08:44:00 +0200
EUCAST 2019 - 20 (ChairmanĀ“s report) https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=377&cHash=54dc6bcdf8df92d283c4c29388d595ce The EUCAST General Committee meeting at ECCMID 2020 was cancelled due to COVID19. The EUCAST... The EUCAST General Committee meeting at ECCMID 2020 was cancelled due to COVID19.

The EUCAST Steering Committee and subcommittees have, under the heading of the traditional ChairmanĀ“s report, summarised the last 12 months of activity. 

In short - these were some of the major achievements during 2019-20:

  • The recruitment of two new Steering Committee members with PK/PD expertise: Shampa Das and Joseph Meletiadis
  • During the year EUCAST has reviewed or determined breakpoints for ceftolozane-tazobactam (new indications and dosing), amikacin, gentamicin and tobramycin, temocillin and cefiderocol. 
  • The release of rapid disk testing methods and breakpoints from positive blood cultures
  • The implementation of the re-defined "I" category: Susceptible--increased exposure for antibacterials and antifungals
  • Breakpoints for Burkholderia pseudomallei
  • Alternative methods for testing Aspergillus against echinocandins
  • The development of a microdilution testing method for dermatophytes
  • The release of the first veterinary breakpoints for florphenicol in cattle
  • The creation of the European Network for Optimisation of Veterinary Antimicrobial Treatment to further VetCAST's work
  • The release of the reference broth microdilution method for Mycobacterium tuberculosis
  • A workshop of international stakeholders to explore the flow-on effects of the new M. tuberculosis  reference method.

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Mon, 04 May 2020 14:17:05 +0200
Daptomycin guidance document updated https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=376&cHash=27410f31294e42f7d60392bf2cabaf50 The EUCAST guidance document on the use of daptomycin in bloodstream infections including... guidance document on the use of daptomycin in bloodstream infections including endocarditis caused by enterococci, now available.]]> Thu, 30 Apr 2020 10:57:46 +0200 Aminoglycoside rationale documents updated https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=375&cHash=326b0c02827b1786dd647a52eabf8214 Aminoglycoside rationale documents updated with new breakpoints and dosages. rationale documents updated with new breakpoints and dosages.]]> Thu, 30 Apr 2020 10:31:00 +0200 Cefiderocol breakpoints and AST methods now available. https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=374&cHash=839808489fb6fb1033af6d8a1c5e7d07 Addendum: Cefiderocol breakpoints and AST methods (30 April, 2020) Addendum: Cefiderocol breakpoints and AST methods (30 April, 2020) ]]> Thu, 30 Apr 2020 09:15:09 +0200 Newsletter from EUCAST VetCAST https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=373&cHash=63355f9ac9d150f2162daa624d60452a A Newsletter (April 2020) from the EUCAST veterinary subcommittee published. Newsletter (April 2020) from the EUCAST veterinary subcommittee published.]]> Wed, 29 Apr 2020 10:20:12 +0200 Daptomycin in Enterococcus infections - EUCAST position paper in CMI https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=372&cHash=88f4e7f2757eaea2fe7210d77fefdee5 Daptomycin in the treatment of enterococcal bloodstream infections and endocarditis: a EUCAST... Daptomycin in the treatment of enterococcal bloodstream infections and endocarditis: a EUCAST position paper Clinical Microbiology and Infection, 2020. https://doi.org/10.1016/j.cmi.<wbr />2020.04.027 (10.1016/j.cmi.2020.04.027)]]> Tue, 28 Apr 2020 08:41:39 +0200 Aminoglycoside guidance document updated https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=371&cHash=ffc8ca3a647022b5e83b21a7af8c039e The guidance document on aminoglycoside dosing, first published 21 January 2020, updated 24 April,... The guidance document on aminoglycoside dosing, first published 21 January 2020, updated 24 April, 2020

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Fri, 24 Apr 2020 21:39:54 +0200
Warnings against pipercaillin-tazobactam gradient tests finally removed. https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=370&cHash=c80c790f0515c9493b60afd22d60dfaa Previous warnings against gradient tests Etest and MTS were finally removed (November 2019 for... warnings against gradient tests Etest and MTS were finally removed (November 2019 for Etest and April 2020 for MTS).]]> Fri, 24 Apr 2020 16:41:09 +0200 Temocillin breakpoints and Rationale document added https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=369&cHash=a6108becf38beba89a37b3762ba57807 Temocillin breakpoints and rationale document is added following a final decision by the EUCAST... breakpoints and rationale document is added following a final decision by the EUCAST Steering Committee 21 April, 2020.]]> Tue, 21 Apr 2020 10:11:09 +0200 Corrected RAST table 2.1 published https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=368&cHash=1fcdbdb9d97edd0334bc378a99f5776b Because of an error in the E. faecalis tab a corrected table was published 20 April, 2020. The... E. faecalis tab a corrected table was published 20 April, 2020. The difference between the previous version (2.0) and the RAST new version (2.1) is only in the E. faecalis tab (highlighted in light blue).]]> Mon, 20 Apr 2020 16:14:48 +0200 EUCAST panels of phenotypically defined strains https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=367&cHash=ed16519ab54b522e316cbf8cc33d2fbe During 2020, EUCAST in collaboration with CCUG (the Culture Collection of the University of... During 2020, EUCAST in collaboration with CCUG (the Culture Collection of the University of Gothenburg), and EUCAST NACs, will make available panels of organisms with phenotypically well characterized levels of susceptibility (MIC-values determined with reference broth microdilution on several occasions before and after freeze drying). Each panel will contain 10 - 25 strains of which a few strains have MICs representative of the wild type of the species, and otherwise strains with typical resistance mechanisms and phenotypically reproducible levels of susceptibility. Each panel will highlight a difficult area of susceptibility testing. They will be useful for laboratories aiming to validate the accuracy of their AST methods, for checking commercial material intended for MIC determination or susceptibility testing (the correct categorisatiopn of S, I and R) and for developers of antimicrobials and AST methods.

Recently EUCAST warned against the use of gradient tests for the determination of benzylpenicillin MICs in S. pneumoniae and before that validated the use of broth microdilution for colistin MIC determination in several species (see https://www.eucast.org/ast_of_bacteria/warnings/). To be able to do this we need to invest much effort into obtaining and characterising strains and their levels of susceptibility using reference methods. In collaboration with colleagues in NACs and at the CCUG we will make selected parts of these collections publicly available.

The first panel consists of 10 Streptococcus pneumoniae with varying levels of susceptibility to betalactam agents and will shortly be made available. More information will follow on the EUCAST (www.eucast.org) and CCUG (www.ccug.se) websites.  

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Sat, 18 Apr 2020 08:31:07 +0200
Aminoglycoside MICs and ECOFFs reviewed https://www.eucast.org/eucast_news/news_singleview/?tx_ttnews%5Btt_news%5D=366&cHash=b1cfcec4cd79cda4edbf509715a9620b Aminoglycoside (amikacin, gentamicin, tobramycin) MIC distributions and ECOFFs reviewed and in some... Aminoglycoside (amikacin, gentamicin, tobramycin) MIC distributions and ECOFFs reviewed and in some cases revised, in accordance with SOP 10.1.

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Sun, 12 Apr 2020 14:24:53 +0200