MIC and zone distributions and ECOFFs

MIC and zone diameter distributions and ECOFFs

Link to MIC and zone diameter distributions and ECOFFs

The website gives MIC distributions (and since 2010 inhibition zone diameter distributions generated with the EUCAST disk diffusion method) for a wide range of organisms and antimicrobial agents, including antifungals.

The distributions are based on collated data from a total of more than 30 000 MIC distributions containing more than several million MICs from worldwide sources.  The distributions include MICs from national and international studies such as resistance surveillance programs (Alexander, BSAC, ECO-SENS, MYSTIC, NORM and SENTRY), as well as MIC distributions from published articles, the pharmaceutical industry drug development programmes, veterinary programmes and from individual laboratories. Histograms display wild type organisms, together with EUCAST epidemiological cut-off values (ECOFFs) and tentative ECOFFs (TECOFF).

 

The distributions should never be referred to in any epidemiological context since data from many time periods and many countries have been aggregated.

 

Using agreed criteria for the acceptance of MIC distributions, the database and ECOFFs are being critically evaluated during 2018 and 2019.  Official ECOFFs are determined by EUCAST, adhering to protocols generated by the "EUCAST Subcommittee on MIC distributions and the determination of ECOFFs" (SOP10 and the document "Considerations in the numerical estimation of ECOFF values" - which will be integrated in SOP10). 

The ECOFFinder program is now available from the EUCAST website. This is a tool made available by EUCAST Scientific Secretary John Turnidge for people wanting to assess MIC distribution data.

Contributions of MIC and Zone diameter distributions can be made using the following Excel file templates: 

 

The following agents and/or species were recently evaluated and ECOFFs revised or confirmed:  

Note that the presence or absence of a resistance mechanism (MRSA vs. MSSA, betalactam withor withot an inhibitor) does not alter the ECOFF which is always decided by the phenotypic expression. Neither does the addition of an inhibitor (unless this has activity of its own) - the ECOFF always pertaines to the active substance.

  • Colistin MIC (2018)
  • Daptomycin MIC (2018)
  • Tigecycline MIC (2018)
  • Florfenicole MIC (2019)
  • Bordetella bronchiseptica MIC (2019)
  • Escherichia coli zone diameter ECOFF (2019)
  • Nalidixic acid MIC ECOFFs review and some revised (Sept 2019).
  • Temocillin TECOFFs for E. coli (16 mg/L), K. pneumoniae (8 mg/L) and P. mirabilis (4 mg/L) as part of the consultation on proposed clinical breakpoints (14 October, 2019).
  • Tedizolid and S. aureus - ECOFF determined to 0.5 mg/L (18 October, 2019).
  • Rifampicin and S. aureus - ECOFF changed from 0.03 to 0.016 mg/L and from ECOFF to TECOFF (19 Oct 2019)
  • Cefazolin and E. coli and Klebsiella pneumoniae - ECOFFs were set to 4 and 4 mg/L, respectively (21 Oct, 2019) 
  • Ciprofloxacin and S. pneumoniae: changed from 2 mg/L to 4 mg/L. (18 Nov, 2019)

 

The curators of the database are currently Gunnar Kahlmeter, Erika Matuschek, Jenny Åhman, Derek Brown and John Turnidge.

Submit MIC distributions to Gunnar Kahlmeter or Erika Matuschek.

 

For Copyright, go to the EUCAST home page.