MIC and zone distributions and ECOFFs

MIC and zone diameter distributions and ECOFFs

Link to MIC and zone diameter distributions and ECOFFs

The website gives MIC distributions (and since 2010 inhibition zone diameter distributions generated with the new EUCAST disk diffusion method) for a wide range of organisms and antimicrobial agents, including antifungals.

The distributions are based on collated data from a total of more than 30 000 MIC distributions containing more than several million MICs from worldwide sources.  The distributions include MICs from national and international studies such as resistance surveillance programs (Alexander, BSAC, ECO-SENS, MYSTIC, NORM and SENTRY), as well as MIC distributions from published articles, the pharmaceutical industry, veterinary programmes and individual laboratories. Histograms display wild type organisms, together with EUCAST epidemiological cut-off values (ECOFFs). The distributions should never be referred to in any epidemiological context since data from many time periods and many countries have been aggregated.


Contributions of MIC and/or Zone diameter distributions can be made using the following Excel file templates:


The ECOFF finder program is now available from the EUCAST website. This is a tool made available by EUCAST Scientific Secretary John Turnidge for people wanting to assess data generated with standardised broth microdilution. Official ECOFFs are determined by EUCAST adhering to protocols generated by the "EUCAST Subcommittee on MIC distributions and the determination of ECOFFs" (SOP10 and the document "Considerations in the numerical estimation of ECOFF values" - which will shortly be integrated in SOP10)



The curators of the database are currently Gunnar Kahlmeter, Erika Matuschek, Jenny Åhman, Derek Brown and John Turnidge.

Submit MIC distributions to Gunnar Kahlmeter or Erika Matuschek.


For Copyright, go to the EUCAST home page.