Veterinary Susceptibility Testing

MIC and Zone diameter distributions for pathogens and agents relevant to the veterinary field

ECOFFs can be used to detect isolates with resistance mechanisms and thus for surveillance of resistance development.

 

For many or most species and agents, clinical breakpoints and ECOFFs will coincide but for some species and agents, isolates with low-level resistance may be clinically susceptible. Likewise, an isolate belonging to the wild type distribution is not by definition clinically susceptible. When in doubt, consult clinical breakpoints or consider non-wild type isolates resistant. 

 

For additional information on wild type distributions and ECOFFs, see:

How to: ECOFFs-the why, the how, and the don'ts of EUCAST epidemiological cutoff values. 

Gunnar Kahlmeter & John Turnidge. Clinical Microbiology and Infection 2022 Jul;28(7):952-954. DOI: 10.1016/j.cmi.2022.02.024

 

Wild-type distributions of minimum inhibitory concentrations and epidemiological cut-off values-laboratory and clinical utility.

Gunnar Kahlmeter & John Turnidge. Clinical Microbiology Reviews 2023. DOI: 10.1128/cmr.00100-22.

 

Graphs showing MIC and zone diameter distributions for species commonly associated with infections in the veterinary field. ECOFFs are listed below graphs together with other statistical parameters. Where a link is not indicated, data is missing. EUCAST is interested in making contact with colleagues in posession of MIC and zone diameter data.