Pharmacokinetic-Pharmacodynamic Cutoff Values for Doxycycline in Pigs to Support the Establishment of Clinical Breakpoints for Antimicrobial Susceptibility Testing.
Toutain PL, Bousquet-Melou A, Ferran AA, Roques BB, Del Castillo JRE, Lees P, Croubels S, Bousquet E, Pelligand L. J Vet Pharmacol Ther. 2025 Jul;48(4):300-317.
Determination of pharmacokinetic-pharmacodynamic cutoff values of Oxytetracycline in calves and adult cattle using population pharmacokinetic modeling.
Winter EA, Pelligand L, Toutain PL, Lees P, Milanova A, Gehring R. Front Microbiol. 2024 Dec 4;15:1498219.
ENOVAT: the European Network for Optimization of Veterinary Antimicrobial Treatment.
Damborg P, Allerton F, Bousquet-Mélou A, Britt C, Cagnardi P, Carmo LP, Cvetkovikj I, Erhard M, Heuvelink A, Jessen LR, Overesch G, Pelligand L, Gómez Raja J, Scahill K, Timofte D, Vale AP, Veldman K, Broens EM. Open Res Eur. 2024 Sep 24;4:170.
Pharmacokinetic–pharmacodynamic cutoff values for benzylpenicillin in horses to support the establishment of clinical breakpoints for benzylpenicillin antimicrobial susceptibility testing in horses.
E. Lallemande et al. Front. Microbiol., 25 October 2023. Volume 14 - 2023 | doi.org/10.3389/fmicb.2023.1282949
Biased computation of probability of target attainment for antimicrobial drugs.
Toutain PL, Gandia P, Pelligand L, Ferran AA, Lees P, Bousquet-Mélou A, Concordet D. CPT Pharmacometrics Syst Pharmacol. 2023 May;12(5):681-689.
The pharmacokinetic/pharmacodynamic paradigm for antimicrobial drugs in veterinary medicine: Recent advances and critical appraisal.
Toutain PL, Pelligand L, Lees P, Bousquet-Mélou A, Ferran AA, Turnidge JD. J Vet Pharmacol Ther. 2021 Mar;44(2):172-200.
Population pharmacokinetics of intravenous amoxicillin combined with clavulanic acid in healthy and critically ill dogs.
MD Vegas Cómitre et al. Front Vet Sci 2021.
Semi-Mechanistic Modeling of Florfenicol Time-Kill Curves and in silico Dose Fractionation for Calf Respiratory Pathogens.
Pelligand L, Lees P, Sidhu PK, Toutain PL. Front Microbiol. 2019 Jun 11;10:1237.
VetCAST Method for Determination of the Pharmacokinetic-Pharmacodynamic Cut-Off Values of a Long-Acting Formulation of Florfenicol to Support Clinical Breakpoints for Florfenicol Antimicrobial Susceptibility Testing in Cattle.
Toutain PL, Sidhu PK, Lees P, Rassouli A, Pelligand L. Front Microbiol. 2019 Jun 12;10:1310.
En Route towards European Clinical Breakpoints for Veterinary Antimicrobial Susceptibility Testing: A Position Paper Explaining the VetCAST Approach.
P-L Toutain et al. Frontiers in Microbiology, December 2017.
Veterinary Medicine Needs New Green Antimicrobial Drugs.
Toutain PL, Ferran AA, Bousquet-Melou A, Pelligand L, Lees P. Front Microbiol. 2016 Aug 3;7:1196. https://doi.org/10.3389/fmicb.2016.01196
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