Subcommittee on Antimycobacterial Susceptibility Testing (AMST)

In November 2014, a workshop in Basel brought together representatives from the EUCAST Steering Committee, the ESCMID Study Group for Mycobacterial Infections (ESGMYC), and the European Medicines Agency (EMA) to discuss data requirements for new anti-tuberculous drugs. A key outcome was the recognition of the utmost importance of identifying a reference method against which other methods can be calibrated — not least for the development of new agents, and to provide pharmaceutical companies with clear instructions on the data that must be submitted to EUCAST for the process of setting breakpoints for Mycobacterium tuberculosis complex and non-tuberculous mycobacteria.

The ESGMYC suggested setting up a subgroup to move forward with the next steps proposed in the workshop report. It was agreed that this would be organised as a EUCAST subcommittee.

  Emmanuelle Cambau

Emmanuelle Cambau

Chair
Paris, France
  Jim Werngren

Jim Werngren

Scientific Secretary
Sweden
  Daniela Cirillo

Daniela Cirillo

Member
Italy
  Fernando Alcaide

Fernando Alcaide

Member
Spain
  Emmanuel André

Emmanuel André

Member
Belgium
  Jakko van Ingen

Jakko van Ingen

Member
The Netherlands
  Miguel Viveiros

Miguel Viveiros

Member
Portugal
  Christoffer Lindemann

Christoffer Lindemann

EUCAST Steering Committee Observer
Norway
  Gunnar Kahlmeter

Gunnar Kahlmeter

EUCAST Steering Committee Observer, Curator of the EUCAST MIC Distribution Database
Sweden
  Christian Giske

Christian Giske

EUCAST Steering Committee Observer
Sweden

Member 

Initials 

Committee 

Country 

Adrian Zelazny 

AZ 

AMST General committee 

US 

Alexandra Aubry 

AA 

AMST General committee 

France 

Alexander Mischnik

AM

AMST General committee 

Germany

Anne Torunn Mengshoel

AT 

AMST General committee 

Norway 

Bettina Schulthess 

BS 

AMST General committee 

Switzerland 

Breida Boyle 

BB 

AMST General committee 

Ireland 

Christian Giske 

CG 

EUCAST Steering committee 

Sweden 

Christoffer Lindemann 

CL 

EUCAST Steering committee 

Norway 

Daniela Cirillo 

DC 

AMST steering committee 

Italy 

Danijela Rajkovic 

DR 

AMST General committee 

Montenegro 

Despo Pieridou 

DP 

AMST General committee 

Cyprus 

Dissou Affolabi 

DA 

AMST General committee 

Benin 

Dorte Bek Folkvardsen 

DF 

AMST General committee 

Denmark 

Dragana Vuković 

DV 

AMST General committee 

Serbia 

Emanuele Borroni 

EB 

AMST General committee 

Italy 

Emmanuel André 

EA 

AMST steering committee 

Belgium 

Emmanuelle Cambau 

EC 

Chair AMST 

France 

Erik Svensson 

ES 

AMST General committee 

Denmark 

Fernando Alcaide 

FA 

AMST steering committee 

Spain 

Gunnar Kahlmeter 

GK 

Tech. cord. Steering committee 

Sweden 

Hanne-Leena Hyyrylainen 

HH 

AMST General committee 

Finland 

Jakko van Ingen 

JVI 

AMST steering committee 

The Netherlands 

Jim Werngren 

JW 

Secretary AMST 

Sweden 

Kadri Klaos 

KK 

AMST General committee 

Estonia 

Laima Vasiliauskaitė

LV

AMST General committee 

Lithuania

Marianne Antar 

MA 

AMST General committee 

Lebanon 

Martin Kuhns 

MK 

AMST General committee 

Germany 

Miguel Viveiros 

MV 

AMST steering committee 

Portugal 

Miguel Santin 

MS 

AMST steering committee 

Spain 

Nazir Ismail 

NI 

AMST General committee 

South Africa 

Olha Konstantynovska 

OK 

AMST General committee 

Ukraine 

Peter Sander 

PS 

AMST General committee 

Switzerland 

Rrezarta Bajrami Halili 

RB 

AMST General committee 

Kosovo 

Špela Klemen 

SK 

AMST General committee 

Slovenia 

Sönke Andres 

SA 

AMST General committee 

Germany 

Thomas Schön 

TS 

AMST General committee 

Sweden 

  1. Define and standardise a reference methodology for MIC-determination of the M. tuberculosis complex and non-tuberculous mycobacteria (NTM).
  2. Develop a SOP for the EUCAST reference MIC method.
  3. Develop a SOP for the calibration of surrogate methods against the EUCAST reference MIC method.
  4. Define a set of quality control strains.
  5. Organise studies to establish reproducibility of the reference method in at least three laboratories.
  6. Organise  studies to generate MIC distributions for the reference strains. The reference MICs will be performed in at least three reference laboratories.
  7. Interact with the EUCAST Steering Committee in the setting of breakpoints for antimycobacterial agents.
  8. Define the relevance of molecular testing and their relationship to phenotypic testing.

Meetings for 2025-26 will be added soon.

Contact

Anyone with an interest in antimicrobial agents in general and antimicrobial breakpoints in particular is invited to contact EUCAST, ESCMID or one of the National Breakpoint Committees. To contact EUCAST use the contact form below. 

Contact form