07.10.2025

Pefloxacin screening for fluoroquinolone resistance in Enterobacterales

Fluoroquinolone breakpoints are under review. Shortly there will be a public consultation.
Since industry and users sometimes complain that EUCAST fails to warn of upcoming changes we now emphasize that (a) a change is coming, (b) breakpoints will be reduced further and that (c) screening for fluoroquinolone resistance using pefloxacin will be an integral part of proposed changes. We urge laboratories and manufacturers to familiarise themselves with the pefloxacin screen test (already described in the EUCAST breakpoint tables for Enterobacterales, Salmonella enterica and Vibrio spp). Also contact your suppliers of material to ensure that they are ready to meet your requirement.