07.05.2025
Proposed revision of breakpoints for trimethoprim-sulfamethoxazole and trimethoprim.
Proposed revision of breakpoints for trimethoprim-sulfamethoxazole and trimethoprim - public consultation 2025-05-07 - 2025-06-18.
The current breakpoints of trimethoprim-sulfamethoxazole are higher than the epidemiological cut-off values for several species. There is absence of PK/PD data for systemic infections, and there is also absence of clinical data linking MIC to outcomes. Thus, the historical clinical breakpoints for Enterobacterales are not well substantiated, and the logical way forward would be to base new breakpoints on ECOFFs, as was recently done for Stenotrophomonas maltophilia.
