







ECOFFs are based on available MIC (and zone diameter) distributions. As more data is generated there is a need to
(1) add new ECOFFs and TECOFFs
(2) revise existing ECOFFs and TECOFFs
(3) remove ECOFFs/TECOFFs where data do not match criteria in SOP 10.1
The table below lists all added ECOFFs and changes to ECOFFs.
Agents | Species | MIC ECOFF from - to | MIC TECOFF from - to | Zone ECOFF from - to | Reason for change | Date | Signed |
---|---|---|---|---|---|---|---|
Eravacycline MIC distributions imported | ECOFFs and TECOFFs for several spec ies | 02 June 2020 | G Kahlmeter & J Turnidge | ||||
Telavancin, Dalbavancin | All species with relevant number of distributions | No changes, a few added | None | 22 May 2020 | G Kahlmeter & J Turnidge | ||
Ceftolozane and ceftolozane-tazobactam | All | Review of all | None | Rationale document revision | 13 May 2020 | G Kahlmeter/J Turnidge | |
Fosfomycin | E. coli | 8 mg/L is too high and is currently under investigation. MIC distributions not generated with agar dilution are removed. with | Only agar dilution is accepted for MIC determination | 27 April 2020 | G Kahlmeter | ||
Gentamicin, Tobramycin, Amikacin | All - review and in some cases revision | As part of systematically reviewing all ECOFFs in accordance with SOP10.1 | 12 April 2020 | G Kahlmeter & J Turnidge | |||
Daptomycin - review and revision (visual and ECOFFinder agree) | All (but most importantly E.faecalis, E. faecium and Staphylococci) | See MIC distribution programme | See MIC distribution programme | Requested review of all MIC data | 06 April 2020 | G Kahlmeter and J Turnidge | |
Temocillin | All species and data available 20200403 curated | Temocillin breakpoints and guidance prepared for publication | 03 April 2020 | G Kahlmeter & J Turnidge | |||
Temocillin | E. coli and K.pneumoniae | 16 (as TECOFF) for E. coli and 8 (as TECOFF) for K.pneumoniae to ECOFFs | Data now consolidated | 23 March 2020 | GK and JT | ||
Ciprofloxacin | All | General review and revision. ECOFFs and TECOFFs changed, added or removed. | 02 March 2020 | ||||
Trimethoprimsulfamethoxazole | All | All ECOFFs reviewed and several revised (E. coli 0.25, most Enterobacterales to 0.5) | General review of data | 21 January 2020 | G Kahlmeter | ||
Ceftolozane and ceftolozane-tazobactam | Several | ECOFFs added | - | - | 25 November 2019 | GK | |
Ciprofloxacin | S. pneumoniae | 2 to 4 mg/L | - | From 20 to 18 mm | 18 November 2019 | GK | |
Cefazolin | E. coli and K.pneumoniae | New ECOFFs 4 mg/L for both | - | - | New ECOFFs | 21 October 2019 | GK |
Rifampicin | S. aureus | ECOFF 0.03 removed (insufficient data) | 0.016 mg/L | 19 October 2019 | GK | ||
Tedizolid | S. aureus | New ECOFF 0.5 mg/L | - | - | Review of all data as part of determining breakpoints | 18 October 2019 | GK |
Temocillin | E. coli, K.pneumoniae, P.mirabilis, Salmonella | ECOFFs determined | E.coli | As part of determining breakpoints | 14 October 2019 | GK | |
Temocillin | E.coli, K.pneumoniae, P.mirabilis | E.coli 16, K.pneumoniae 8 and P.mirabilis 4 mg/L | Review of all temocillin data | 14 October 2019 | GK | ||
Nalidixic acid | Review all | General review of all nalidixic acid ECOFFs; some removed, some changed | 30 September 2019 | GK | |||
All | E. coli | - | - | All zone diameter ECOFFs updated | 28 February 2019 | GK | |
All | Bordetella bronchiseptica | New ECOFFs | New ECOFFs | 31 January 2019 | VetCAST | ||
Florfenicole | All | New | New | ECOFFs determined for the first tiime | 31 January 2019 | VetCAST | |
Tigecycline | Full review | See website | See website | Review of all data | 01 January 2019 | GK JT | |
Colistin | E. coli, K.pneumoniae, Ac. baumanni and Ps. aeruginosa | E.coli, K.pneumoniae and Ac. baumannii 2 mg/L; Ps. aeruginosa 4 mg/L | - | - | Review of all available data | 31 December 2018 | GK JT |
Daptomycin | E.faecalis and E. faecium | New ECOFFs are 4 (E.faecalis) and 8 (E.faecium) mg/L | Review of all daptomycin data | 30 December 2018 | GK |