ECOFF review and revision
ECOFFs are based on available MIC (and zone diameter) distributions.
As more data is generated there is a need to
(1) add new ECOFFs and TECOFFs
(2) revise existing ECOFFs and TECOFFs
(3) remove ECOFFs/TECOFFs where data do not match criteria in SOP 10.1
Currently all MIC distributions are reviewed in accordance with criteria in SOP 10.1. Mostly this is by agent, but on occasion, by species. The table below lists reviewed and revised agents and species.
Ecoff Table
| Agents | Species | MIC ECOFF from - to | MIC TECOFF from - to | Zone ECOFF from - to | Reason for change | Date | Signed |
|---|---|---|---|---|---|---|---|
| Gentamicin | Campylobacter spp | 1 to 2 mg/L | - | New calculation | 21 February 2022 | G Kahlmeter & J Turnidhe | |
| Delafloxacin | All | First time ECOFFs | New agent - ECOFFs previously not determined. | 07 January 2022 | G Kahlmeter & J Turnidhe | ||
| Omadacycline | All available | All ECOFFs reviewed | - | Primary dtermination of ECOFFs | 06 December 2021 | G Kahlmeter & J Turnidge | |
| Lefamulin | All | Initial ECOFFs | - | Initial ECOFF determination | 01 December 2021 | G Kahlmeter & J Turnidge | |
| All | Bacillus cereus | All ECOFFs determined | - | First data assessment | 15 November 2021 | G Kahlmeter & J Turnidge | |
| All | Burkholderia pseudomallei | MICs defined | - | Data assessed | 28 October 2021 | G Kahlmeter & J Turnidge | |
| Narasin | All available | All | - | Data first assessment | 18 October 2021 | G Kahlmeter & J Turnidge | |
| Vancomycin, teicoplanin, telavancin, dalbavancin and oritavancin | All, as part of the 2020-21 general review of the complete database. | Several | Several | the 2020-21 general review of the complete database. | 23 August 2021 | G Kahlmeter & J Turnidge | |
| Azithromycin, Telithromycin, Spiramycin, Tulathromycin | All available species | Several - se distribution programme | Several - se distribution programme | Part of the 2020-2021 review and revision of the entire database | 18 August 2021 | G Kahlmeter & J Turnidge | |
| Erythromycin & Clarithromycin | All species reviewed | Several, as part of the 2021 review of the entire MIC database | Several, as part of the 2021 review of the entire MIC database | The 2021 SOP 10.1 review of the total database. | 27 July 2021 | G Kahlmeter & J Turnidge | |
| Trimethoprim-sulfamethoxazole & Trimethoprim | All species reviewed | Several changed following an SOP 10.1 review | Several changed following an SOP 10.1 review | Part of the 2021 review of the entire MIC database. | 27 July 2021 | G Kahlmeter & J Turnidge | |
| Rifampicin | All; general review | Several ECOFFs added, removed or changed | Part of the general 2021 curating of database in accordance with SOP 10.1 | 22 July 2021 | G Kahlmeter & J Turnidge | ||
| Chloramphenicol | All available distributions | Several changed, removed or added | Several changed, removed or added | Part of the general 2021 curation of database | 27 May 2021 | G Kahlmeter & J Turnidge | |
| Colistin | All curated | No change | Added two | Part of the general 2021 curation of database | 27 May 2021 | G Kahlmeter & J Turnidge | |
| Amoxicillin, amoxicillin-clavulanic acid | All available distributions curated | Several | Several | Part of the general 2021 curation | 27 May 2021 | G Kahlmeter & J Turnidge | |
| Ampicillin | All species reviewed | Several revised | Several revised | Part of the general curating of database 2021. | 19 May 2021 | G Kahlmeter & J Turnidge | |
| Meropenem | All species reviewed | Several revised | Several revised | 15 May 2021 | G Kahlmeter & J Turnidge | ||
| Aminoglycosides | All species | All | All | Part of the general curating of database | 12 May 2021 | G Kahlmeter & J Turnidge | |
| All available | Mannheimia hemolytica | All curated | All curated | Gnereal review initiated by VetCAST | 04 May 2021 | G Kahlmeter, J Turnidge & K Veldman | |
| All available agents curated | Pasteurella multocida | All curated | All curated | General review initiated by VetCAST | 25 April 2021 | G Kahlmeter, J Turnidge & K Veldman | |
| All available agents | Staphylococcus pseudintermedius | All curated | All curated | General review initiated by VetCAST | 25 April 2021 | G Kahlmeter, J Turnidge & K Veldman | |
| All available | Staphylococcus hyicus | Added, all curated | Added, all curated | General review initiated by VetCAST | 22 April 2021 | G Kahlmeter, J Turnidge, Kees Veldman | |
| Eravacycline MIC distributions imported | ECOFFs and TECOFFs for several spec ies | 02 June 2020 | G Kahlmeter & J Turnidge | ||||
| Telavancin, Dalbavancin | All species with relevant number of distributions | No changes, a few added | None | 22 May 2020 | G Kahlmeter & J Turnidge | ||
| Ceftolozane and ceftolozane-tazobactam | All | Review of all | None | Rationale document revision | 13 May 2020 | G Kahlmeter/J Turnidge | |
| Fosfomycin | E. coli | 8 mg/L is too high and is currently under investigation. MIC distributions not generated with agar dilution are removed. with | Only agar dilution is accepted for MIC determination | 27 April 2020 | G Kahlmeter | ||
| Gentamicin, Tobramycin, Amikacin | All - review and in some cases revision | As part of systematically reviewing all ECOFFs in accordance with SOP10.1 | 12 April 2020 | G Kahlmeter & J Turnidge | |||
| Daptomycin - review and revision (visual and ECOFFinder agree) | All (but most importantly E.faecalis, E. faecium and Staphylococci) | See MIC distribution programme | See MIC distribution programme | Requested review of all MIC data | 06 April 2020 | G Kahlmeter and J Turnidge | |
| Temocillin | All species and data available 20200403 curated | Temocillin breakpoints and guidance prepared for publication | 03 April 2020 | G Kahlmeter & J Turnidge | |||
| Temocillin | E. coli and K.pneumoniae | 16 (as TECOFF) for E. coli and 8 (as TECOFF) for K.pneumoniae to ECOFFs | Data now consolidated | 23 March 2020 | GK and JT | ||
| Ciprofloxacin | All | General review and revision. ECOFFs and TECOFFs changed, added or removed. | 02 March 2020 | ||||
| Trimethoprimsulfamethoxazole | All | All ECOFFs reviewed and several revised (E. coli 0.25, most Enterobacterales to 0.5) | General review of data | 21 January 2020 | G Kahlmeter | ||
| Ceftolozane and ceftolozane-tazobactam | Several | ECOFFs added | - | - | 25 November 2019 | GK | |
| Ciprofloxacin | S. pneumoniae | 2 to 4 mg/L | - | From 20 to 18 mm | 18 November 2019 | GK | |
| Cefazolin | E. coli and K.pneumoniae | New ECOFFs 4 mg/L for both | - | - | New ECOFFs | 21 October 2019 | GK |
| Rifampicin | S. aureus | ECOFF 0.03 removed (insufficient data) | 0.016 mg/L | 19 October 2019 | GK | ||
| Tedizolid | S. aureus | New ECOFF 0.5 mg/L | - | - | Review of all data as part of determining breakpoints | 18 October 2019 | GK |
| Temocillin | E. coli, K.pneumoniae, P.mirabilis, Salmonella | ECOFFs determined | E.coli | As part of determining breakpoints | 14 October 2019 | GK | |
| Temocillin | E.coli, K.pneumoniae, P.mirabilis | E.coli 16, K.pneumoniae 8 and P.mirabilis 4 mg/L | Review of all temocillin data | 14 October 2019 | GK | ||
| Nalidixic acid | Review all | General review of all nalidixic acid ECOFFs; some removed, some changed | 30 September 2019 | GK | |||
| All | E. coli | - | - | All zone diameter ECOFFs updated | 28 February 2019 | GK | |
| All | Bordetella bronchiseptica | New ECOFFs | New ECOFFs | 31 January 2019 | VetCAST | ||
| Florfenicole | All | New | New | ECOFFs determined for the first tiime | 31 January 2019 | VetCAST | |
| Tigecycline | Full review | See website | See website | Review of all data | 01 January 2019 | GK JT | |
| Colistin | E. coli, K.pneumoniae, Ac. baumanni and Ps. aeruginosa | E.coli, K.pneumoniae and Ac. baumannii 2 mg/L; Ps. aeruginosa 4 mg/L | - | - | Review of all available data | 31 December 2018 | GK JT |
| Daptomycin | E.faecalis and E. faecium | New ECOFFs are 4 (E.faecalis) and 8 (E.faecium) mg/L | Review of all daptomycin data | 30 December 2018 | GK |
