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General

Updated warning on cefiderocol AST

Investigations into the problems with susceptibility testing of species with breakpoints for cefiderocol have been performed by EUCAST and others. The warning has been updated 16 August, 2022. Work is continued and further updates may be expected.

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The 2023 preliminary breakpoint table now available for comments and questions.

The next breakpoint table (valid from 1 Jan, 2023) is now available for comments and questions. Please address comments to erika.matuschek[at]eucast.org or gunnar.kahlmeter[at]eucast.org no later than 19 December, 2022.

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Planned updates to breakpoint table v 11.0

Striving to keep EUCAST users informed of upcoming changes, this short document describes the planned major changes to the breakpoint tables v 11.0 (2021). The table itself will be published for consultation on or about 5 December, 2020.

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Candida auris - comments to consultation and EUCAST AFST responses and actions

EUCAST AFST recently proposed new breakpoints for amphotericin B, three echinocandins and flucytosine against Candida auris . A public consultation was held 2025-03-06 - 2025-04-17. Now (2025-06-17) the EUCAST AFST has responded to comments .

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Invitation to EUCAST general updates via zoom

This is a general invitation to attend EUCAST zoom updates on the 11th of November (8 AM, 1 PM and 4 PM). Current EUCAST projects will be described, the next breakpoint table summarised and there will be opportunities to discuss.

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RAST breakpoints for prolonged incubation (16-20h) now published in JAC

Recently we made breakpoints available (on the website) for RAST incubation beyond the standard 4, 6 and 8h for when reading at those incubation times is not prectical. Now the rationale for this is published in the Journal of Antimicrobial Chemotherapy .

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Streptococcus pneumoniae and benzylpenicillin susceptibility testing.

We are frequently asked questions regarding (1) EUCAST Warning No. 7 : is this warning specifically directed at benzylpenicillin gradient tests (Etest TM , bioMérieux, and MTS TM , Liofilchem) when used for Streptococcus pneumoniae or does it apply to other bacteria, (2) is it still valid or have we…

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All MIC/Zone diameter calibration file updated. Anaerobic bacteria added.

With changes in the breakpoint table v 12.0 and the adding of disk diffusion criteria for anaerobic bacterial and for Vibrio spp, the calibration filesshowing the relationship between MIC and inhibition zone diameters ​​​​​​​ need updating. These are now available (Vibrio spp to follow).

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Expert rules, Staphylococcus spp updated

The Staphylococcus spp. Expert Rules document was updated 1 Febr, 2023. The detection of benzylpenicillin resistance in S. lugdunensis is based on the breakpoints only - the assessment of inhibition zome edge has been removed fro S. lugdunensis but remains for S. aureus .

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News from VetCAST - publication on PK/PD for benzylpenicillin in horses

Pharmacokinetic–pharmacodynamic cutoff values for benzylpenicillin in horses to support the establishment of clinical breakpoints for benzylpenicillin antimicrobial susceptibility testing in horses. E.Lallemande et al, October, 2023.Front. Microbiol., 25 October 2023.Volume 14 - 2023 |…

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