Rationale Documents The EUCAST Rationale Documents currently available are listed below. Rationale documents for antifungal agents are listed elsewhere, see " Antifungal rationale documents ". A template for companies aiming to create a comprehensive rationale document for new agents or for existing…
Get to know morePublications and Presentations 2025 2023 2022 2020 Archive The Mycobacterium tuberculosis complex based on the EUCAST reference protocol. Mansjö M, Espinosa-Gongora C, Samanci I, Groenheit R, Werngren J. Antimicrob Agents Chemother. 2025 Feb 13;69(2):e0094624. doi: 10.1128/aac.00946-24. Epub 2024…
Get to know moreThis is to clarify how "susceptibility (S and I)" and "resistance (R)" should be reported in AMR surveillance with the EUCAST definitions of S I and R . With the EUCAST definitions, the tradition to report "non-susceptibility" as the joint rate of %I and %R is abandoned. Previously (pre-2019) it was…
Get to know moreResistance Detection in RAST Some resistance mechanisms require other than clinical breakpoints for sensitive detection. EUCAST has validated using separate screening cut-offs for the detection of E. coli and K. pneumoniae with ESBL or carbapenemases. Screening for resistance mechanisms using RAST…
Get to know moreSusceptibility testing of fastidious organisms - is there an alternative to MH-F ? Public consultation 2025-06-19 - 08-29. The EUCAST medium MH-F was developed for AST of fastidious organisms.Colleagues in some areas of the world have difficulties obtaining the MH-F plate based on horse blood. The…
Get to know moreThe database of MIC and zone diameter distributions was created by Gunnar Kahlmeter for EUCAST from 2002 and onwards. More data is regularly added and all data is curated by Gunnar Kahlmeter and John Turnidge. The website gives MIC distributions and inhibition zone diameter distributions for…
Get to know moreEUCAST distributions of MIC and Zone diameters (https:/mic.eucast.org; choose either “MIC” or “Disk diffusion”) are freely available. When sufficiently many acceptable distributions are available to the curators, ECOFFs are determined and listed beneath each graph together with confidence intervals.…
Get to know moreRationale documents Amphotericin B v 3.0 (26 June 2025) Anidulafungin vs. Candida v 5.0 (26 June 2025) Caspofungin vs Candida - there is no caspofungin RD and no specific caspofungin breakpoints. Use anidulafungin and micafungin as markers for caspofungin susceptibility where isolates "S" to both…
Get to know moreThe manufacturer of antimicrobial susceptibility testing material is responsible for the quality of the material provided to microbiological laboratories. The laboratory is responsible for the result provided to doctors and patients. To perform AST where there is intrinsic resistance is wasting the…
Get to know moreDisk diffusion of anaerobic bacteria in 16-20 hours (9 December, 2021; at 8AM , 1PM and 4PM CET to satisfy different time zones; link below). EUCAST has developed a disk diffusion method for AST of 5 anaerobic species (Bacteroides spp, Prevotella spp, Fusobacterium necrophorum, Clostridium…
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