Development of Clinical Breakpoints and ECOFFs These pages collate information on the definition of clinical breakpoints and the process of setting MIC breakpoints. Background information is given in the Rationale Documents and in Public Consultations and the MIC:ZD (MIC vs. zone diameter)…
Get to know moreSetting Breakpoints Breakpoints for phenotypic antimicrobial susceptibility testing have been determined by breakpoint committees and as part of regulatory processes for the approval of new drugs since the 1970s. Knowledge of dosage, modes of administration, target infections and clinical outcome…
Get to know moreEUCAST is proposing to change colistin breakpoints to breakpoints in brackets . The consultation is open for comments between 6 October - 15 November. In breakpoint table v 12.0 (2022), EUCAST aims to introduce brackets for colistin breakpoints. The same model has been used previously for…
Get to know moreThe first and very important question is, when are there no breakpoints in the EUCAST breakpoint tables? Look for guidance on the interpretation of test results in breakpoint tables , expert rules and in EUCAST advice on expected phenotypes . In breakpoint tables guidance can be in the form of…
Get to know moreClinical breakpoint table (Yeast and moulds) Breakpoints and methods for susceptibility testing of yeasts, moulds and dermatophytes are developed and validated by the EUCAST subcommittee on AFST. Document Description Clinical breakpoints for fungi v. 12.0 PDF file for printing; valid from 26 June,…
Get to know moreDocument Archive Breakpoint tables for fungi QC tables Methodology Rationale documents Clinical breakpoints for fungi (v 11.0) - pdf file for printing (until 26 June, 2025) Clinical breakpoints for fungi (v 11.0) - excel file for screen (until 26 June, 2025) Clinical breakpoints for fungi (v 10.0) -…
Get to know moreMIC and zone diameter breakpoints for aztreonam-avibactam and cefepime-enmetazobactam are now available as addenda to the clinical breakpoint table 14.0. The breakpoints will be integrated in the regular breakpoint table 15.0, 1 Jan, 2025.
Get to know moreEUCAST introduced breakpoints in brackets in 2020. In breakpoint table 12.0 (2022) there are breakpoints in brackets for aminoglycosides, colistin and for clindamycin for Bacteroides spp. A guidance document describes how to interpret and report breakpoints in brackets.
Get to know moreBreakpoints for Rapid AST Breakpoints validated for EUCAST short incubation disk diffusion directly from positive blood culture bottles. For interpretation of rapid AST directly from blood culture bottles, reading and interpreting inhibition zones after 4 hours, 6 hours, 8 hours and 16-20 hours,…
Get to know moreMycobacteria (AMST) The EUCAST AMST develops breakpoints and methods for antimicrobial susceptibility testing of mycobacteria. Clinical breakpoints for Mycobacteria are part of the regular EUCAST breakpoint table for bacteria. For MIC distributions for Mycobacterium tuberculosis and other…
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