The EUCAST Veterinary committee has released three rationale documents for consultation (comments no later than 8 January, 2024)
Get to know moreCompanies are requested to complete a "company rationale document" to aid the EUCAST process of setting breakpoints for new agents. A template has been available for many years. It is now revised .
Get to know moreRationale Documents EUCAST rationale documents summarise the information on which the EUCAST clinical breakpoints are based. Bedaquiline Rationale for EUCAST clinical breakpoints Version 1.3, 4 July 2019 Download PDF Bedaquiline (TMC207) is a diarylquinoline, a new class of anti-tuberculosis (TB)…
Get to know moreVeterinary Committee on Antimicrobial Susceptibility Testing (VetCAST) VetCAST is a EUCAST subcommittee dealing with all aspects of antimicrobial susceptibility testing of bacterial pathogens of animal origin and animal bacteria with zoonotic potential. Subcommittee Discover More Development of…
Get to know moreEUCAST is currently in the process of reviewing and updating the format of all rationale documents . It is a major and very resource consuming task. Three RDs (cefiderocole, ceftriaxone, tigecycline) have now been published in the the new format, one of which did not previously exist. Old versions…
Get to know moreDevelopment of Clinical Breakpoints and ECOFFs The EUCAST AMST develops breakpoints and methods for antimicrobial susceptibility testing of mycobacteria. Rationale Documents Discover More Public Consultations A chance to review proposed EUCAST changes. Discover More Submit non-truncated MIC…
Get to know moreDevelopment of clinical breakpoints and ECOFFs How to collect and handle PK data Supporting information Guideline VetCAST PK analysis Author: VetCAST Date 06/04/18 Download PDF Guideline to collect, archive, handle and analyse pharmacokinetic data for VetCAST The purpose of this Guideline document…
Get to know moreReference Method The EUCAST reference method for the Mycobacterium tuberculosis complex is broth microdilution in Middlebrook 7H9. See following documents for further information. EUCAST reference protocol for MIC determination of anti-tuberculous agents against isolates of the Mycobacterium…
Get to know moreHow to interpret MICs of amphotericin B, echinocandins and flucytosine againstCandida auris(Candidozyma auris) according to the newly established EUCAST breakpoints. Maiken Cavling Arendrup et al. CMI 2025 (preprint) Objectives. The aim was to present an overview of the newly established ECOFFs and…
Get to know moreInformation for pharmaceutical companies intending to bring new antimicrobial drugs to EUCAST for breakpoints The development of clinical breakpoints for new agents requires agreement and acceptance of the data generated in support of decisions on clinical breakpoints, wild type MIC distributions,…
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