Rationale Documents from EUCAST
The EUCAST Rationale Documents currently available are listed below. Rationale documents for antifungal agents are listed elsewhere, see Antifungal rationale documents".
A template for companies aiming to create a comprehensive rationale document for new agents or for existing agents where a breakpoint change is proposed, is available at Template for producing a Rationale Document (26 June 2014). The template is under revision.
Archived RDs, not immediately available from the list below, can be obtained from the webmaster.
Rationale Documents for antibacterial agents:
When there are discrepancies between RDs and EUCAST breakpoint Tables or dosing recommendations, always refer to the current version of the breakpoint table.
2023: All Rationale Documents (RD) are currently under review and a new format has been agreed. The new RDs will be published in two sections as they are readied. Section one for updated RDs, section two for RDs in line for update. As RDs are updated to the new format, old versions will be archived and not immediately available but can be obtained from the webmaster on request.
Section 1 (RDs updated and converted to new format)
- Cefiderocol 2.0 (2023-04-04). MIC and zone diameter correlates for cefiderocol.
- Ceftriaxone 1.0 (2023-04-04).
- Tigecycline 3.0 (2023-04-04).
Section 2 (RDs waiting to be updated and converted to new format)
- Amikacin v 2.0 (2020-04-30)
- Amoxicillin v 1.0 (2010-11-22)
- Bedaquiline v 1.0 (2019-07-04)
- Benzylpenicillin v 1.0 (2010-11-22)
- Cefiderocol v 1.1 (2022-03-11) - archived
- Cefotaxime v 1.0 (2010-09-26)
- Ceftaroline v 1.0 (2014-10-10)
- Ceftazidime v 1.0 (2010-09-26)
- Ceftazidime-avibactam v 1.0 (2020-07-30)
- Ceftobiprole v 1.0 (2016-03-31)
- Ceftolozane-tazobactam v 1.0 (2020-05-15)
- Cefuroxime iv v 1.0 (2010-09-26)
- Ciprofloxacin v 2.0 (2021-02-08)
- Colistin v 1.0 (2010-05-27)
- Daptomycin v 2.0 (2021-05-12); Daptomycin v 1.0
- Delafloxacin v 1.2 (2022-01-17), Delafloxacin v 1.1 (2021-04-17); Delafloxacin v 1.0 (2021-02-08)
- Delamanid v 1.2 (2019-0704)
- Doripenem v 1.0 (2009-06-01)
- Doxycycline v 1.0 (2009-11-20)
- Ertapenem v 2.0 (2021-02-08)
- Florfenicol (from VetCast) v 1.0 (2019-08-10)
- Fosfomycin v 1.0 (2013-02-15)
- Fosfomycin-trometamol v 1.0 (2013-02-15)
- Fusidic acid v 1.0 (2010-04-14)
- Gentamicin v 2.0 (2020-04-30)
- Imipenem v 2.0 (2021-02-08)
- Imipenem-relebactam v. 1.0 (2021-02-08)
- Levofloxacin v 2.0 (2021-02-08)
- Linezolid v 1.0 (2005-11-18)
- Mecillinam v 1.0 (2010-11-22)
- Meropenem v 2.0 (2021-02-08)
- Meropenem-vaborbactam v 1.0 (2021-02-08)
- Metronidazole v 1.0 (2010-01-11)
- Minocycline v 1.0 (2009-11-20)
- Moxifloxacin v 3.0 (2021-02-08)
- Mupirocin v 1.0 (2010-07-06)
- Netilmicin v 1.1 (2020-01-21)
- Nitrofurantoin v 1.0 (2010-03-21)
- Nitroxoline v 1.0 (2016-11-11)
- Norfloxacin v 1.4 (2007-08-22)
- Ofloxacin v 1.4 (2007-08-22)
- Phenoxymethylpenicillin v 1.0 (2010-11-22)
- Piperacillin-tazobactam v 1.0 (2010-11-22)
- Rifampicin v 1.0 (2010-04-14)
- Spectinomycin v 1.0 (2009-06-09)
- Teicoplanin v 2.1 (2010-06-17)
- Tedizolid v 1.0 (2018-04-19)
- Temocillin v 1.0 (2020-04-21)
- Tetracycline v 1.0 (2009-11-20)
- Tigecycline v 2.0 (2022-07-21) - archived
- Tobramycin v 2.0 (2020-04-30)
- Trimethoprim v 1.0 (2010-09-26)
- Trimethoprim-sulfamethoxazole v 1.0 (2017-06-05)
- Vancomycin v 2.1 (2010-06-17)