Publications by EUCAST in peer-reviewed journals

John Turnidge, Sören Gatermann, Gunnar Kahlmeter, Rafael Cant, Mandy Wootton, Christian G. Giske on behalf of the European Committee on Antimicrobial Susceptibility Testing.

Anja Berger, Edgar Badell, Jenny Åhman, Erika Matuschek, Nora Zidane, Gunnar Kahlmeter, Andreas Sing and Sylvain Brisse. J Antimicrob Chemother 2024 https://doi.org/10.1093/jac/dkae056.  

Flavia Dematheis, Viviana Manzulli, Gregor Grass, Erika Matuschek, Daniela Jacob, Falk Melzer, Mandy Elschner, Agnieszka Kedrak-Jablonska, Sylwia Budniak, Marcella Mori, Tiziano Fancello, Roland Grunow, Gunnar Kahlmeter, Domenico Galante, Sabine Zange. Clin Microbiol Infect 2024 Jun 7:S1198-743X(24)00256-8. DOI: 10.1016/j.cmi.2024.05.019

Onur Karatuna, Erika Matuschek, Jenny Åhman, Hayat Caidi and Gunnar Kahlmeter. Journal of Antimicrobial Chemotherapy, December 2023. 

Gunnar Kahlmeter & John Turnidge. Clin Microbiol Rev. December 1, 2023. 

Fröberg G, Maurer FP, Chryssanthou E, Fernström L, Benmansour H, Boarbi S, Mengshoel AT, Keller PM, Viveiros M, Machado D, Fitzgibbon MM, Mok S, Werngren J, Cirillo DM, Alcaide F, Hyyryläinen HL, Aubry A, Andres S, Nadarajan D, Svensson E, Turnidge J, Giske CG, Kahlmeter G, Cambau E, van Ingen J, Schön T; EUCAST AMST and ESCMYC study groups.

Clin Microbiol Infect. 2023 Jun;29(6):758-764. doi: 10.1016/j.cmi.2023.02.007. 

Erika Matuschek, Sarah Copsey-Mawer, Sara Petersson, Jenny Åhman, Trefor Elis Morris, Gunnar Kahlmeter. CMI, https://doi.org/10.1016/j.cmi.2023.01.027

Céline Plainvert, Erika Matuschek, Nicolas Dmytruk, Marine Gaillard, Amandine Frigo, Yassine Ballaa, Eddy Biesaga, Gunnar Kahlmeter, Claire Poyart, Asmaa Tazi. Microbiol Spectr. 2023 Jun 15;11(3):e0016023. 

Erika Matuschek, Christopher Longshaw, Miki Takemura, Yoshinori Yamano, Gunnar Kahlmeter. 

Journal of Antimicrobial Chemotherapy.  https://doi.org/10.1093/jac/dkac080

G Kahlmeter, J. Turnidge. A narrative review, CMI 2022. 

https://doi.org/10.1016/j.cmi.2022.02.024

Erika Matuschek, Alma Brolund, Oskar Karlsson Lindsjö, Christian G. Giske, Sara Byfors, Gunnar Kahlmeter. CMI; April 23, 2021. DOI:https://doi.org/10.1016/j.cmi.2021.04.014 

Supplementary material.

Herjan Bavelaar, Ulrik Stenz Justesen, Trefor E Morris, Bethan Anderson, Sarah Copsey-Mawer, Tore Taksdal Stubhaug, Gunnar Kahlmeter, Erika Matuschek. CMI, April 2021.

Christian G Giske, Gunnar Kahlmeter, Alasdair MacGowan, John Turnidge on behalf of the EUCAST Steering Committee. JAC Link.

Comments on a recently published paper by Alexandre et al. (J Antimicrob Chemother 2021; 76:784-8) which demonstrated good clinical efficacy of temocillin in the treatment of infections originating from the urinary tract. EUCAST agrees with the overall conclusion that temocillin has proven clinical efficacy in infections originating from the urinary tract. However, there are several conclusions in the paper that need further discussion.

After a long review process and public consultation, EUCAST concluded that 2 g × 3 will ensure successful outcomes in all patients with infections originating in the urinary tract. The breakpoints susceptible ≤0.001 mg/L and resistant >16 mg/L avoid dividing the WT of relevant organisms and increase the chance of reproducible susceptibility results. These conclusions are in line with official recommendations both in France and other EU countries where the drug is available.

J. Turnidge, G. Kahlmeter, R. Cantón, A. MacGowan, C.G. Giske, on behalf of theEuropean Committee on Antimicrobial Susceptibility Testing. CMI 26, P1039-1043, 2020 (https://doi.org/10.1016/j.cmi.2020.04.027). 

See also the EUCAST guidance document on the use of daptomycin in enterococci.

1. Mycobacterium tuberculosis drug-resistance testing: challenges, recent developments and perspectives. 

2. Antimicrobial susceptibility testing of Mycobacterium tuberculosis complex isolates - the EUCAST broth microdilution reference method for MIC determination

3. Multicentre testing of the EUCAST broth microdilution reference method for MIC determination on Mycobacterium tuberculosis

4. What is the role of the EUCAST reference method for MIC testing of the Mycobacterium tuberculosis complex?

EUCAST articles in relation to MIC distributions and ECOFFs of Mycobacterium tuberculosis.

1. The EUCAST rapid disc diffusion method for antimicrobial susceptibility testing

directly from positive blood culture bottles. Emma Jonasson et al. JAC 2019.

2. EUCAST rapid antimicrobial susceptibility testing (RAST) in blood cultures:

validation in 55 European laboratories. Anna Åkerlund et al. JAC 2020. 

3. Evaluation of prolonged incubation time of 16-20 h with the EUCAST rapid antimicrobial susceptibility disc diffusion testing method. Emma Jonasson et al, JAC 2023

O Karatuna, D A B Dance, E Matuschek, J Åhman, P Turner, J Hopkins, P Amornchai, V Wuthiekanun, T-P Cusack, R Baird, J Hennessy, R Norton, M Armstrong, S Zange, L Zoeller, T Wahab, D Jacob, R Grunow, G Kahlmeter

DOI: 10.1016/j.cmi.2020.07.001

1. The quality of antimicrobial discs from nine manufacturers - EUCAST evaluations in 2014 and 2017. Jenny Åhman et al. CMI, 2019

2. EUCAST evaluation of 21 brands of Mueller-Hinton dehydrated media for disk diffusion testing (Supplementary material). Jenny Åhman et al, CMI, 2020.

3. Evaluation of 10 brands of pre-poured Mueller Hinton agar plates for EUCAST disk diffusion. Jenny Åhman et al, CMI 2022.

1st report in CMI from the EUCAST Subcommittee on the role of whole genome sequencing in antimicrobial susceptibility testing. M. J. Ellington et al., CMI 2015. 

EUCAST – are we heading towards international agreement? 

Gunnar Kahlmeter. JAC 2015, Sep;70(9):2427-39. doi: 10.1093/jac/dkv145

Widespread implementation of EUCAST breakpoints for antibacterial susceptibility testing in Europe. Eurosurveillance, Volume 20, Issue 2, 15 January 2015. D Brown, R Cantón, L Dubreuil, S Gatermann, C Giske, A MacGowan, L Martínez-Martínez, J Mouton, R Skov, M Steinbakk, C Walton, O Heuer, M J Struelens, L Diaz Högberg, G Kahlmeter.

EUCAST Disk Diffusion Method. E. Matuschek, D. F. J. Brown and G. Kahlmeter. Published in CMI 2013

The role of pharmacokinetics/pharmacodynamics in setting clinical
MIC breakpoints - the EUCAST approach (published in CMI 2012)

J. W. Mouton, D. F. J. Brown, P. Apfalter, R. Canton, C. G. Giske, M. Ivanova, A. P. MacGowan, A. Rodloff, C.-J. Soussy, M. Steinbakk and G. Kahlmeter. CMI 2012.

EUCAST Expert rules in antimicrobial susceptibility testing.
R. Leclercq, R. Canton, D. F. J. Brown, C. G. Giske, P. Heisig, A. P. MacGowan, J. W. Mouton, P. Nordmann, A. C. Rodloff, G. M. Rossolini, C.-J. Soussy, M. Steinbakk, T. G. Winstanley and G. Kahlmeter. CMI 2012.

European Committee for Antimicrobial Susceptibility Testing (EUCAST) of the European Society for Clinical Microbiology and Infectious Diseases (ESCMID). EUCAST Discussion Document E. Dis 5.1: determination of minimum inhibitory concentrations (MICs) of antibacterial agents by broth dilution. Clin Microbiol Infec 2003; 9 (insert): 1-7.
Link to full document

This discussion document was not developed into a EUCAST definitive document because EUCAST was aware of the proposed development of an international (ISO) standard for broth microdilution, which was eventually published in 2006.